neavs org biomedical research

I am not aware of any publication that has examined the comparative rigor with which studies using different species (for example, rodents versus NHPs or other large animals) have been performed. WebThats why we created the animal protection movements first publicly accessible research and transparency toolthe Animal Research Laboratory Overview (ARLO). In many cases, preclinical investigations that have avoided use of NHPs have failed, for example for development of therapies for tuberculosis (Foreman et al. Richard Stouffer and Teresa Woodruff review the use of NHPs to study critical issues related to womens reproductive health. . I am a psychologist and President of New England Anti-Vivisection Society. 4 0 obj Neeves. Matthew Banks and colleagues review many of the preclinical studies aimed at understanding the etiology of substance abuse disorders (drug addiction) and developing therapies using preclinical animal models, particularly NHPs. It will be important for the NHP research community to have a discussion with NIH to fully understand expectations for NHP-based grant proposals. For nearly 20 years, Coulston conducts invasive experiments on chimpanzees. Alternatives like in vitro, computer simulations, cell and tissue samples, and mannequins are reducing the millions of sentient animals forced into painful experiments worldwide. C (2) To conduct high impact research They summarize data for disorders associated with ovarian and uterine function and deleterious conditions associated with pregnancy. JE JD Spring 2005. Specifically, I thank the NPRC Directors, Drs. A particularly timely example is development of a highly efficacious vaccine for HIV/AIDS. In 1983 NEAVS successfully lobbied to repeal Massachusetts' 1957 pound seizure law, which required animal shelters to sell animals for use in research. There is no good solution to this problem, which is outside the control of the end users of the animals. KKA KA Some basic discoveries may be obtained from studies using rodents (reviewed by Zubari and Lutz 2016) and other models, such as zebrafish (Danio rario), fruit flies (Drosophila melanogaster), and nematodes (Caenorhabditis elegans) (reviewed by Strange (2017)). With the support of people like you, we save animals from Cox These new requirements will be challenging for investigators proposing NHP-based research and for peer reviewers, in part because of the expense associated with each animal in an NHP-based study and the potential difficulty of obtaining adequate numbers of females, neonates, or juveniles. The authors point out that there are still important medical issues regarding Hepatitis, such as the development of curative therapies for chronic Hepatitis B, as opposed to the successful development of vaccines to thwart new infections, and the development of a vaccine for Hepatitis C, as opposed to the successful development of antivirals. Much of this discussion is centered around the use of rodents, not NHPs, and is based, in part, on two observations: First, data obtained from animal models obtained by academic laboratories and their industrial collaborators, published in highly regarded peer-reviewed journals, often cannot be reproduced by development teams within pharmaceutical companies. 2014; other examples reviewed by Hewitt et al. WebThe National Gene Vector Biorepository. Lanford WebAccording to our records, this business is located at 45 Memorial Cir in Augusta (in Kennebec County), Maine 04330, the location GPS coordinates are: 44.3101021 (latitude), -69.7801427 (longitude). 2016). 2017). Capaldo and her newly elected board of directors came with extensive animal protection and animal rights experience and have included individuals with medical, veterinary, psychology, mental health, sociology, and legal credentials, such as Sarah Luick, Esq., a founding member of the Animal Legal Defense Fund (ALDF). Animal research is generally recognized to be costly, time-consuming, and unreliable, and much of this research is neither appropriate nor applicable to humans. Biomedical Research - American Anti-Vivisection Society This issue of the journal includes a review of procedures for environmental enrichment, which helps assure animal health and wellbeing. Due to logistical issues and member relocation the chapter went inactive in 2005 until Steve Knight, Nicole Ball, Sue Maguire and Jack Siegel re-activated the NNEVS in 2009. These authors discuss many aspects of preclinical studies using NHPs, including the necessity for having the proper containment facilities, and the ability to study the effects of co-morbidities such as infection by simian immunodeficiency virus (leading potentially to simian AIDS), long-term exposure to alcohol, and diabetes. Search for other works by this author on: Trial watch: Phase II and Phase III attrition rates, 20112012, Raise standards for preclinical cancer research, Whole-genome characterization in pedigreed non-human primates using genotyping-by-sequencing (GBS) and imputation, Whole genome sequencing predicts novel human disease models in rhesus macaques, Naturally-occurring nonhuman primate models of psychosocial processes, Contributions of non-human primates to neuroscience research, Progress and prospects for genetic modification of nonhuman primate models in biomedical research, Genome editing in nonhuman primates: Approach to generating human disease models, Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9, Exome screening to identify loss-of-function mutations in the rhesus macaque for development of preclinical models of human disease, Baboons as a model to study genetics and epigenetics of human disease, Nonhuman primates and translational researchcardiovascular disease, Marmosets are stars of Japans ambitious brain project, A rhesus macaque model of Asian-lineage Zika virus infection, Translational research in the nonhuman primate model of tuberculosis, Comparison of the Canadian and US laws, regulations, policies and systems of oversight for animals in research, Progress in genetics and genomics of nonhuman primates, Genomic tools for the use of nonhuman primates in translational research, Use and importance of nonhuman primates in metabolic disease research: Current state of the field, Clinical development success rates for investigational drugs, Accelerating biomedical discoveries through rigor and transparency, A second generation human haplotype map of over 3.1 million SNPs, Development and validation of a SNP-based assay for inferring the genetic ancestry of rhesus macaques (Macaca mulatta), TALEN-based generation of a cynomolgus monkey disease model for human microcephaly, Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research, The chimpanzee model of viral hepatitis: Advances in understanding the immune response and treatment of viral hepatitis, Autism-like behaviors and germline transmission in transgenic monkeys overexpressing MeCP2, The next step in translational research: Lessons learned from the first preclinical randomized controlled trial, Bringing genome-wide association findings into clinical use, In retrospect: A decade of shared genomic associations, Advances in vision science and prevention of blindness using nonhuman primates, National Association for Biomedical Research, National Research Council (US) Institute for Laboratory Animal Research, Laboratory animal laws, regulations, guidelines and standards in China Mainland, Japan and Korea, Protecting animals and enabling research in the European Union: An overview of development and implementation of directive 2010/63/EU, Generation of transgenic marmosets expressing genetically encoded calcium indicators. Want updates when NEAVS has new information, or want to find more organizations like Rise for Animals (NEAVS)? [48], In the 21st century billions of animals have been used for human's benefit through animal testing of consumer products, in the United States and dozens of other countries. 2016 ANNUAL REPORT The short generation times of mice and their fecundity contribute to the success of these technologies. WebNEW ENGLAND ANTI-VIVISECTION SOCIETY 333 Washington Street, Suite 850 Boston, MA 02108 Phone: 617-523-6020 Fax: 617-523-7925 Email: info@neavs.org neavs.org 2016 brought enormous success to NEAVS long-standing focus on non-animal alternatives and chimpanzees. , Browne WJ, Cuthill IC, Emerson M, Altman DG. HIV/AIDS vaccine development is one of the most important and difficult goals of modern translational medicine. NEAVS The preclinical research essential for meeting these goals requires use of NHP preclinical models. These conditions are correlated with negative health outcomes in humans, including development of autism and asthma. Peter Havel and colleagues review the use of NHP preclinical models for metabolic conditions, concentrating on obesity and metabolic syndrome. One species for which a supply-demand problem does potentially exist at present in the United States is the marmoset, which may be particularly useful for neurobiological studies and for development of new NHP disease models using genetic engineering and assisted reproductive technologies (Belmonte et al. The New England Anti-Vivisection Society, founded in 1895, works to expose and replace animal experiments in laboratories and classrooms with ethically and scientifically responsible modern alternative research methods. Although it would be impractical to publish the entire animal record for each experimental subject, these records contain a great deal of information that could be mined by qualified investigators to aid in the design of experiments and to form the basis of retrospective studies that could include animals or tissues derived from them from several different centers and investigations. PJ The Endangered Lab Chimp | Science Funding agencies, in collaboration with investigators, may need to find mechanisms to increase support for NHP-related investigations that require larger numbers of certain types of animals, such as females. In the past several years, there has been considerable discussion regarding the reproducibility of animal studies and therefore the utility of animals for translational research. The website for the US National Primate Research Centers (NPRCs) includes short discussions of the use of NHPs to study several different diseases (https://www.nprcresearch.org). Neeves, D.M. M.J. Osmond, E. Korthals, C.J. Similar regulations and mechanisms exist in Europe (for reviews, see Bayne and Morris 2012; Olsson et al. Given the complexity of translational research and the fact that any animal model cannot totally reproduce the human condition, there are many challenges and opportunities when NHPs are used for translation. CROs may both breed and import animals, where importation is possible. Human vaccine trials based on NHP preclinical models have not demonstrated sufficient efficacy to warrant large-scale application to human populations but have provided critical information that can be used to develop more effective vaccines (Office of AIDS Research 2017; Van Rompay 2017; Veazey and Lackner 2017, and references therein). NEAVS' campaign against hormone replacement therapy drugs made from the urine of pregnant horses encourages women to use alternatives. G S Our vision is to use engineering science to discover mechanisms that regulate blood disorders and innate immunity, and to exploit those mechanisms to develop diagnostic and drug delivery technologies. These nonprofit centers seldom import animals. [25][28][26], NEAVS launched its national Project R&R: Release and Restitution for Chimpanzees in U.S. Laboratories campaign in 2003 to end the use of chimpanzees in invasive biomedical research and provide them permanent homes in sanctuary. Prinz neavs John Capitanio describes research that identifies individual rhesus macaques housed at the California NPRC that can be used as models for loneliness, behavioral inhibition, and social functioning, among others. [39] On June 11, 2013, FWS proposed changing the policy and opened a public comment period. National Association for Biomedical Research Research using all vertebrate animals, including NHPs, and the characteristics of the facilities that house and breed animals are regulated in North America (Griffin and Locke 2016; Tardif et al. They cite approaches to vaccine development that were first tested successfully in NHPs and have now moved to Phase II human clinical trials and also make the point that some vaccine approaches that appeared to be successful in mice, but were not tested in NHPs, failed in humans. The purpose of mentioning them is to acknowledge that there are potential alternatives to NHPs and other animal models. A therapy or vaccine may, in its first application to humans, provide only partial efficacy or may raise critical questions that can only be answered by going back to animal models.

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